✅ The ranking (best → worst)
Here’s the gist of his order, with what he highlights about each:
- Chicory root syrup – Ranks best. He notes this syrup is rich in inulin (a prebiotic fibre), has a minimal rapid-sugar spike, and supports gut-microbiome health.
- Dates – High up. Whole fruit fibre + micronutrients slow absorption and feed healthier gut bacteria.
- Raw honey – Strong marks. Minimally processed, has antimicrobial and prebiotic potential (especially unprocessed/local types).
- Monk fruit sweetener – Mid-high. Plant-derived, low glycemic load, minimal evidence of gut disruption (though caveats on processing).
- Stevia – Mid-range. Calorie-free, plant-derived, but he cautions: many products contain fillers, and long-term microbiome data is limited.
- Coconut sugar – Slightly better than the common refined sweeteners. Has trace minerals and lower glycemic index than white sugar — but still significant impact.
- Brown sugar – Just marginally better than the worst options. Because it’s still largely sucrose with molasses added.
- Artificial sweeteners (like sucralose/aspartame) – He ranks these better than the worst but still in the danger zone: they don’t act like “healthy” just because they’re low-calorie. They may disrupt gut flora and metabolism.
- Refined white sugar – Near the bottom. He cites rapid absorption, blood-sugar spikes, feeding less-desirable gut bacteria, and offering little beyond calories.
- High‑fructose corn syrup (HFCS) – Ranked worst. Highly processed, heavy in fructose metabolism load (especially for the liver), frequent gut-microbiome disruption.
🔍 Key take-aways & cautions
- “Natural” doesn’t always mean harmless. For example, coconut sugar is natural but still exerts strong metabolic effects.
- The gut-microbiome focus: Dr Sethi emphasises how sweeteners can alter gut-flora, influence inflammation and even appetite/craving signals.
- Artificial sweeteners, though zero or low-calorie, aren’t a free pass. Some large reviews (by Harvard Health Publishing) show possible links with metabolic issues, blood-pressure changes and gut-microbiome shifts.
- The best strategy: Choose whole-food sweeteners (fruits, dates, etc), reduce overall sweetness of diet, and treat added sweeteners as occasional.
- Individual variation matters: If someone has gut-issues, diabetes, liver-concerns or other conditions — sweetener choice may need to be more cautious and personalised.
📝 My verdict for Indian context
For readers in India, this ranking is useful as a guideline — but here are a few nuances to mind:
- Dates, honey and chicory-root syrup may cost more or may not be used as commonly in everyday sweets (Indian mithai, desserts, etc). So cultural adaptation is needed.
- Many processed foods and Indian sweets still rely heavily on white sugar or HFCS (in imported or packaged goods) — so the biggest gains come from reducing use of the worst ones rather than chasing a perfect “sweetener”.
- When using alternatives like stevia or monk fruit, check what else is added (fillers, sugar alcohols) because those can also affect digestion/gut.
- Moderation is key: Even “better” sweeteners still add sweetness and may affect taste-preferences (making you crave more sweet foods) or gut health if over-used.

